In this issue of Veterinary Clinics: Small Animal Practice, guest editors Drs. Felix Duerr and Lindsay Elam bring their considerable expertise to the topic of Small Animal Orthopedic Medicine. Mobility and orthopedic challenges are common issues that can negatively impact the quality of life and overall health of small animal companion pets. This issue covers a wide range of topics to help practicing veterinarians identify, assess, treat, and manage orthopedic and mobility issues in pets.