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Dr. Afrin earned a B.S. in computer science at Clemson University in 1984 and then an M.D. at the Medical University of South Carolina (MUSC) in 1988, where he also pursued internal medicine residency and hematology/oncology clinical and research fellowships. While on faculty at MUSC from 1995-2014, he was active in undergraduate and graduate medical education, educational and information technology administration, and practice and research in hematology/oncology and medical informatics. Since the mid-'00s, his clinical work has increasingly focused in hematology, especially mast cell disease. In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments - quite different from one patient to the next - of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen - even the relief that comes from finally having a unifying diagnosis other than "psychosomatism" - have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so "unlucky" to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that) which has the biological capability to develop, directly or indirectly, into most or all their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. He joined the University of Minnesota in 2014 to further his interests in this area. He has an extensive record of peer-reviewed publications and has spoken widely in his areas of interest. If you have questions pertaining to Dr. Afrin's book, or would like more information, please email info@mastcellresearch.com. You can also visit www.mastcellresearch.com. Or, find us on Facebook @facebook.com/mastcellresearch/, and Twitter @MastCellHelp.

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The big guy is back – Donkey Kong swings into action with a brand new adventure on Nintendo Switch 2! Help Donkey Kong on his journey through the depths of the underground. The deeper he goes, the more amazing places he finds! With his powerful punches, DK can pulverize a seemingly endless variety of things. Experience your breakthrough in this thoroughly destructive adventure. A mysterious gang called VoidCo is already lying in wait for this valuable haul. But no one gets away with stealing DK's favorite food! Discover the golden bananas. Golden bananas?! The discovery of this tasty treasure sends the entire island into a frenzy. And then – disaster strikes! Game type EAN 0045496312756 Manufacturer no. 10016190 Platform Nintendo Switch 2 Edition Standard Age rating USK Approved for ages 6 and up Genre Adventure System requirements VR compatible No Portal Nintendo

A new-edition of the issue-driven young adult vision of star-crossed lovers in a divided world, with cover art tying in to the BBC production. The series continues to be relevant fifteen years after release in its depictions of racism and terrorism.

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Test your knowledge and prepare for the OCA/OCP exams OCA/OCP Java SE 8 Programmer Practice Tests complements the Sybex OCA: Oracle Certified Associate Java SE 8 Programmer I Certification Study Guide and the OCP: Oracle Certified Professional Java SE 8 Programmer II Study Guide for exams 1Z0-808 and 1ZO-809 by providing last minute review of 100% of exam objectives. Get the advantage of over 1,000 expert crafted questions that not only provide the answer, but also give detailed explanations. You will have access to unique practice questions that cover all 21 objective domains in the OCA/OCP exams in the format you desire--test questions can also be accessed via the Sybex interactive learning environment. Two additional practice exams will ensure that you are ready for exam day. Whether you have studied with Sybex study guides for your OCA/OCP or have used another brand, this is your chance to test your skills. * Access to all practice questions online with the Sybex interactive learning environment * Over 1,000 unique practice questions and 2 practice exams include expert explanations * Covers 100% of all 21 OCA/OCP objective domains for Exams 1Z0-809 and 1Z0-809 Studying the objectives are one thing, but diving deeper and uncovering areas where further attention is needed can increase your chance of exam day success. Full coverage of all domains shows you what to expect on exam day, and accompanying explanations help you pinpoint which objectives deserve another look.

The legendary 1951 scroll draft of On the Road, published as Kerouac originally composed it“The sparse and unassuming scroll is the living version [of On the Road] for our time. . . . It is a dazzling piece of writing.”—The New York Times Book ReviewDuring three weeks in 1951, Jack Kerouac wrote the first draft of On the Road—typed as a long, single-spaced paragraph on eight sheets of tracing paper, which he taped together to form a scroll. Representing the identifiable point at which his vision and narrative voice first came together in a sustained burst of creative energy, the scroll is the “uncut” version of Kerouac’s masterpiece—rougher, wilder, and more sexually explicit than the edited work that appeared in 1957. On the Road: The Original Scroll is Kerouac’s signature achievement—and one of the most significant, celebrated, and provocative documents in American literary history.Penguin Classics is the leading publisher of classic literature in the English-speaking world, representing a global bookshelf of the best works throughout history and across genres and disciplines. Readers trust the series to provide authoritative texts enhanced by introductions and notes by distinguished scholars and contemporary authors, as well as up-to-date translations by award-winning translators.

A new "Percy The Park Keeper" adventure marking the thirtieth anniversary of the animal series. Includes surprise fold-out page.